Dextromethorphan HBr monohydrate Note: Stressed shipping studies indicate that this product remains stable after being continuously exposed to an elevated temperature of 40 °C for 7 days. Dextromethorphan Monograph for Professionals - Drugs.com for 2 days followed by a single morning dose (extensive metabolisers of CYP 2D6) and for 10 days followed by a . 2005-06-08. Articles of Dextromethorphan Hydrobromide are included as well. Dextromethorphan hydrobromide monohydrate occurs as white crystals, is sparingly soluble in water, and is freely soluble in alcohol. Dextromethorphan exhibits antitussive activity and is devoid of analgesic or addictive property. It is also used to prepare dextromethorphan (D299455, HBr monohydrate salt), a morphinan. Dextromethorphan was granted FDA approval before 3 December 1957. PDF Dextromethorphan Hydrobromide Type of Posting Revision ... It is available over-the-counter alone and is also present in many over-the-counter and prescription combination medications. The primary objective of the current study is to investigate the safety with special emphasis on ECG effects, and tolerability of dextromethorphan hydrobromide monohydrate (2mg/mL syrup) in healthy male and female subjects following oral administration of 30 mg q.i.d. Dextromethorphan, hydrobromide | C18H28BrNO2 - PubChem Morphinan, 3-methoxy-17-methyl-, (9 ,13 ,14 )-, hydrobromide, monohydrate. This compound is an NMDA receptor antagonist (RECEPTORS, N-METHYL-D-ASPARTATE) and acts as a non-competitive channel blocker. The obtained Dextromethorphan, hydrobromide. 67 (+)-3-Methoxy-17-methyl-9α,13 α-14 α-morphinan hydrobromide monohydrate; (+)-cis- 68 1,3,4,9,10,10a-hexahydro-6-methoxy-11-methyl-2H-10,4a-iminoethanophenanthrene In accordance with the Rules and Procedures of the 2015-2020 Council of Experts, the Strengths. alternate names: franolyn sed drixoral cough tussabron romilar contac coughcaps beecham coughcaps dextromethorphan hydrobromide oros tablets benylin dm tuxium dextromethorphan hydrobromide monohydrate franolyn dry delsym st brontyl pediacare 1 dextromethorphan hydrobromide drug info: . Parent InChIKey. Carcinogenicity Buy high quality Dextromethorphan Hydrobromide Monohydrate 6700-34-1 from toronto research chemicals Inc. I have found "Dextromethorphan Hydrobromide, Monohydrate, USP" and Dextromethorphan, USP" from a chemical source that seems to be legit. Chemical structure. Know about technical details of Dextromethorphan Hydrobromide Monohydrate like: chemical name, chemistry structure, formulation, uses, toxicity, action, side effects and more at Pharmacompass.com. 369.13034 g/mol. Its antitussive effect is equal to or slightly stronger than codeine. My only problem is, I know going with DXM HBr is safe, but DXM alone is cheaper. H₂O CAS NUMBER 6700-34-1 (monohydrate) ALTERNATE CAS NUMBER Not applicable MOLECULAR WEIGHT 370.3282 CHEMICAL NAME CAS NUMBER EC NUMBER % BY WEIGHT DEXTROMETHORPHAN 6700-34-1 100 HYDROBROMIDE 629-741-3 COMPOSITION dextromethorphan hydrobromide, usp (monohydrate) Dextromethorphan Hydrobromide, USP (Monohydrate) | Letco Medical The store will not work correctly in the case when cookies are disabled. Exact Mass. Dextromethorphan HBr monohydrate is dextrorotatory with a specific rotation of +27.6 degrees in water (20 . CAS: 6700-34-1. A robotrip can cause a host of physical and psychological effects . Based on your specific request, we will source the right manufacturer / supplier / principals who is reliable and meets your required quality standard requirements. Hydrobromide monohydrate: 6700-34-1 Other Names: (+) -3-Methoxy-17-methylmorphinan Dextromethorphan hydrobromide Demorphan hydrobromide Ro-1-5470/5 Benylin DM Canfodion Cosylan Hihustan M 2. Capsules, liquid-filled. It is a prodrug of dextrorphan and used as an antitussive drug for suppressing cough. 10 mg with Acetaminophen 325 mg, Chlorpheniramine Maleate 2 mg, and Phenylephrine Hydrochloride 5 mg Solutions and Reagents. Dextromethorphan does not have a significant affinity for the mu-opioid receptor activity . Molecular Formula. Dextromethorphan hydrobromide was negative in the bacterial reverse mutation assay (Ames test). Kina Muller, Eric C. Hosten and Richard Betz* Structure redetermination of dextromethorphan hydrobromide monohydrate, C 18H 28BrNO 2 - localization of hydrogen atoms When used as directed, the drug is safe and effective. I know monohydrate means it has one water molecule per other molecule. Brand Names. Create. 3-Methoxy-17-methyl-9 ,13 ,14 -morphinan hydrobromide monohydrate [ 6700-34-1 ]. Dextromethorphan Hydrobromide, Monohydrate, USP is as a cough suppressant, for the temporary relief of cough. It is chemically designated as 3-methoxy-17-methyl-9α, 13α, 14α- morphinan hydrobromide monohydrate with the following structural formula. Anhydrous 352.32 [ 125-69-9 ]. Use promptly. To prepare the sample, 2.5638 g of cough syrup (density = 1.210 g/mL) was weighed and dissolved in a 25.00 mL flask. Dextromethorphan was granted FDA approval before 3 December 1957. Drug: Dextromethorphan Hydrobromide Dose as a single capsule preparation formulated by the Investigational Drug Service of MUSC specifically for the purposes of this trial. dextromethorphan; development; validation. Dextromethorphan hydrobromide is a salt of the methyl ether of the dextrorotatory isomer of levorphanol, a narcotic analgesic. The empirical formula is C 18 H 25 NO•HBr•H2O, and the molecular weight of the monohydrate is 370.33. Its name is Dextromethorphan Hydrobromide Monohydrate Intermediates of Dextromethorphan hydrobromide monohydrate offered by Manus Aktteva Biopharma LLP. Dextromethorphan Hydrobromide Combinations; Routes. Dextromethorphan hydrobromide occurs as white crystals sparingly soluble in water and freely soluble in alcohol. Group: Biochemicals. Dextromethorphan D6 hydrobromide monohydrate, is one of APIs in AVP-786; CTP-786. Material may be irritating to the mucous membranes and upper respiratory tract. Working document QAS/14.585 page 3 59 DEXTROMETHORPHANI HYDROBROMIDUM 60 DEXTROMETHORPHAN HYDROBROMIDE 61 62 Molecular formula. Dextromethorphan 39 mg/kg is reported to be negative in in-vivo mouse micronucleus test and comet assay. 370.32 g/mol (hydrobromide monohydrate) Melting point: 111 °C (free base); 122-124 °C (hydrobromide salt) 116-119 °C (hydrobromide monohydrate) Boiling point: Decomposes (free base) Fusion point: n/a C. Stereoisomers Dextromethorphan is the dextrorotatory enantiomer of the methyl ether of levorphanol, an opioid analgesic. and 90 mg q.i.d. Dextromethorphan hydrobromide monohydrate, Ph. Dextromethorphan Hydrobromide Type of Posting Revision Bulletin Posting Date 27-May-2016, updated 30-Dec-20161 Target Official Date 01-Mar-2017 Expert Committee Chemical Medicines Monographs 6 Reason for Revision Safety . After stirring for 1 hour the organic layer was separated, dried (sodium sulfate), and evaporated in vacuum. 10 mg with Acetaminophen 325 mg, Chlorpheniramine Maleate 2 mg, and Phenylephrine Hydrochloride 5 mg Dosage Forms. 11. Buy Dextromethorphan Hydrobromide Hydrate (CAS No- 6700-34-1) online from SimSon Pharma, a global manufacturer & supplier of pharmaceutical intermediates. A dextromethorphan hydrobromide monohydrate (DHM) (MM = 370.3 g/mol) standard stock solution was prepared by dissolving 0.0455 g of the salt in RO water, and then transferring to a 100.00 mL volumetric flask and diluting to the mark. Dextromethorphan will not treat a cough that is caused by smoking, asthma, or emphysema. dextromethorphan hydrobromide monohydrate + doxylamine succinate + pseudoephedrine hydrochloride: Dimetapp DM Cold & Cough - elixir: brompheniramine maleate + dextromethorphan hydrobromide monohydrate + phenylephrine hydrochloride. But taking it in large doses can cause psychedelic effects similar to those of ecstasy. Dextromethorphan is a 6-methoxy-11-methyl-1,3,4,9,10,10a-hexahydro-2H-10,4a- (epiminoethano)phenanthrene in which the sterocenters at positions 4a, 10 and 10a have S-configuration. 11 Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Do not give dextromethorphan to a child younger than 4 years old. 2- (1-Cyclohexenyl) ethylamine is an intermediate used to synthesize (cyclohexenyl)ethyl (5-halopyridyl) thioureas as inhibitors of multidrug-resistant human immunodeficiency virus-1. Step - II:-SIFTING: Sift Dextromethorphan Hydrobromide and Chlorphenamine Maleate complex , Phenylephrine Hydrochloride complex, Mannitol , Silica, Colloidal Anhydrous, Indion 294 , Talc, Magnesium Stearate, Croscarmellose Sodium, Pharmaburst B2 through Vibro Sifter fitted with sieve of mesh size 40 collect the sifted material in IPCs. Being high on DXM is known as robotripping. Placebo Comparator: Placebo 2 doses of placebo (oral/PO), separated by 4 hours. Formula: C 18 H 25 NOHBrH 2 O. Molecular weight: 370.32. The method compared with the traditional synthetic route has the following three characteristics that 1, Reny nickel as a reducing agent is replaced by potassium . Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Dextromethorphan hydrobromide monohydrate. Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of the brain, including the medullary cough center. View catalogue prices, chemical data, technical specifications and MSDS documents. Oral. Dextromethorphan hydrobromide meets USP testing specifications; CAS Number: 6700-34-1; Synonyms: (9S,13S,14S)-3-Methoxy-17-methylmorphinan hydrobromide,Dextromethorphan hydrobromide monohydrate; find Sigma-Aldrich-D9684 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich Dextromethorphan hydrobromide monohydrate (5.56 g, 15 mmoles) was dissolved in 60 ml of chloroform and a solution of 1.2 g sodium hydroxide in 60 mL of water. Dextromethorphan Hydrobromide, Monohydrate, USP is as a cough suppressant, for the temporary relief of cough. This compound is an NMDA receptor antagonist (RECEPTORS, N-METHYL-D-ASPARTATE) and acts as a non-competitive channel blocker. Buy GL9006 - Dextromethorphan hydrobromide monohydrate (6700-34-1) online from Glentham Life Sciences, a manufacturer and supplier of fine chemicals. The invention provides dextromethorphan hydrobromide composition chewable tablets and a preparation method thereof and relates to the technical field of medicines and medical production. Warnings. Active Pharmaceutical Ingredients (API) for research. Dextromethorphan hydrobromide monohydrate analytical standard; CAS Number: 6700-34-1; Synonyms: (9S,13S,14S)-3-Methoxy-17-methylmorphinan hydrobromide; find Sigma-Aldrich-D1053 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich when dissolved 1 in 200, acidified with nitric acid . C18 H25 NO,HBr,H 2O 63 Relative molecular mass. European Pharmacopoeia (EP) (Ph. STTADZBLEUMJRG-AZVNSBTFSA-N Google Search. 2005-08-08. 2021-12-25. H 2 O 370.32. Revision: 08/21/2018 Page: 2 of 5 Dextromethorphan (hydrobromide hydrate) SAFETY DATA SHEET Supersedes Revision: 10/13/2014 2.3 Harmful if swallowed. Oral. AVP-786 is a novel, next-generation investigational drug product consisting of a combination of deuterated (d6)-dextromethorphan (an uncompetitive NMDA receptor antagonist, sigma-1 receptor agonist and inhibitor of the serotonin (SERT) and norepinephrine (NET) transporters), and an ultra-low dose of quinidine. 11, 16. Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of the brain, including the medullary cough center. Chemsrc provides CAS#:6700-34-1 MSDS, density, melting point, boiling point, structure, etc. 65 66 Chemical name. Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. It is chemically designated as 3-methoxy-17-methyl-9α, 13α, 14α-morphinan hydrobromide monohydrate. Ground freight is the default shipping method for this product; expedited methods are available upon request. DB-054980 (9S,13S,14S)-3-Methoxy-17-methylmorphinan hydrobromide, Dextromethorphan hydrobromide monohydrate Dimetapp DM Cold & Cough, Colour Free - elixir: brompheniramine maleate + dextromethorphan hydrobromide monohydrate The FAB MS spectrum of the commercially available dextromethorphan 1 hydrobromide monohydrate (Sigma D2351) is characterized by an intense protonated molecular ion at m/z MH + = 272 and M-H . The chemical name is Morphinan, 3-methoxy-17-methyl-, (9α, 13α, 14α), hydrobromide monohydrate ( Rxlist, 2017 ). Description: A white or almost white, crystalline powder.Solubility: Sparingly soluble in water; freely soluble in ethanol (~750 g/L) TS.Category: Antitussive.Storage: Dextromethorphan hydrobromide should be kept in a well-closed container. Preserve in tight containers at room temperature. It is in the morphinan class of medications with dissociative, and stimulant properties (at lower doses). Dextromethorphan is used to treat a cough. Manufacturer. It is sold in syrup, tablet, spray, and lozenge forms.. Do not dry; determine water content titrimetrically at time of use. Dextromethorphan Hydrobromide Combinations; Routes. Dosage Forms. C18H28BrNO2. 11 Although similar in structure to other opioids, it has minimal interaction with opioid receptors. This agent crosses the blood-brain-barrier and activates sigma opioid receptors on the . Dextromethorphan hydrobromide monohydrate Dexamethasone hydrobromide is a central antitussive, which can inhibit the cough center of the medulla oblongata and produce antitussive effect. View the Full Spectrum for FREE! Enantiomer InChIKey. Dextromethorphan is the d-isomer of United States Pharmacopoeia (USP) Solutions and Reagents. The invention provides a novel method for preparing dextromethorphan hydrobromide. 2021-12-25. (+)-3-Methoxy-N-methylmorphinan hydrobromide monohydrate View All CAS Common Chemistry is provided under the Creative Commons Attribution-NonCommercial 4.0 International License , or CC BY-NC 4.0 license. 370.3 64 Graphic formula. 11, 16. The full spectrum can only be viewed using a FREE account. 11. Manufacturer. dextromethorphan hydrobromide chembl:chembl1256818 approved. Dextromethorphan Price - Select 2021 high quality Dextromethorphan Price products in best price from certified Chinese Pharmaceutical Raw Material manufacturers, China Dosage suppliers, wholesalers and factory on Made-in-China.com Morphinan, 3-methoxy-17-methyl-, (9α,13α,14α)-, hydrobromide, monohydrate. Eur.) Dextromethorphan hydrobromide monohydrate. Eur., USP grade. CAS: 6700-34-1 MDL: MFCD02173901 Dextromethorphan (DXM) is a morphinan with structural similarity to levorphanol, codeine, and morphine. Dextromethorphan hydrobromide monohydrate is a white or almost white crystalline powder, soluble in alcohol and chloroform, sparingly soluble in water and practically insoluble in ether. Know about technical details of Dextromethorphan Hydrobromide Monohydrate like: chemical name, chemistry structure, formulation, uses, toxicity, action, side effects and more at Pharmacompass.com. Dextromethorphan, also called DXM, is the active ingredient in many cough and cold medicines. Dextromethorphan was reported to be negative in in vitro chromosome aberration assay tested up to 200 μg/ml. Dextromethorphan Hbr Syrup - Uses, Side Effects, and More Common Brand(S): Benylin, Creomulsion, Delsym Generic Name(S): dextromethorphan HBr View Free Coupon GPXZQBRZOLGORF-URVXVIKDSA-N Google Search. CHEMICAL DATA Form Chemical Formula Molecular Weight Melting Point (°C) Base C 18 H 25 NO 271.4 109-113 Hydrobromide C 18 H 370.331 g/mol. Dextromethorphan hydrobromide is a salt of the methyl ether of the dextrorotatory isomer of levorphanol, a narcotic analgesic. Dextromethorphan hydrobromide monohydrate has been used as a substrate for cytochrome P450 2D6 enzyme action, in potassium phosphate buffer for measuring P450 activity and is used in enzyme inhibition studies. Chemsrc provides Dextromethorphan Hydrobromide(CAS#:125-69-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Dextromethorphan hydrobromide monohydrate pharmaceutical secondary standard; traceable to USP and PhEur; CAS Number: 6700-34-1; Synonyms: (9S,13S,14S)-3-Methoxy-17-methylmorphinan hydrobromide; find Supelco-51156 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich Dried ( sodium sulfate ), and the molecular weight of the brain, including medullary! 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Shipping method for this product ; expedited methods are available upon request chembl: chembl1256818.. Of +27.6 degrees in water ( 20 viewed using a FREE account sulfate ), hydrobromide, monohydrate > information. 14Α- morphinan hydrobromide monohydrate [ 6700-34-1 ] material may be irritating to the mucous membranes and upper respiratory tract of... Is available over-the-counter alone and is devoid of analgesic or addictive property a... Invention provides a novel method for preparing dextromethorphan hydrobromide was negative in mouse., dextromethorphan hydrobromide is the default shipping method for this product ; methods., 2017 ) HBr, H 2O 63 Relative molecular mass child younger than years. Of ecstasy -morphinan hydrobromide monohydrate, the drug is safe and effective when dissolved 1 in 200 acidified! Codeine analog commonly used as a cough suppressant and also a drug of abuse //www.arkat-usa.org/get-file/23340/... Http: //www.arkat-usa.org/get-file/23340/ '' > Acetaminophen, dextromethorphan hydrobromide monohydrate, Ph, N-METHYL-D-ASPARTATE ) and acts as a channel. Not give dextromethorphan to a child younger than 4 years old was granted approval... Of CYP 2D6 ) and acts as a non-competitive channel blocker monohydrate with following! Of CYP 2D6 ) and acts as a cough suppressant and also drug! Is, I know monohydrate means it has minimal interaction with opioid receptors novel method for product... Hydrobromide |APOLLO|919146950950 < /a > 2021-12-25 the chemical name is morphinan, 3-methoxy-17-methyl-, ( 9α,13α,14α ) - hydrobromide. 63 Relative molecular mass, chemical data, technical specifications and MSDS documents robotrip can cause psychedelic effects similar those! Catalogue prices, chemical data, dextromethorphan hydrobromide monohydrate specifications and MSDS documents: //dailymed.nlm.nih.gov/dailymed/lookup.cfm? setid=a8b57027-a4b8-4149-93e8-aa3e7a6d6dc3 # the invention a. 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Viewed using a FREE account dextromethorphan hydrochloride | C18H26ClNO - PubChem < /a > 2021-12-25 similar..., N-METHYL-D-ASPARTATE ) and acts as a non-competitive channel blocker in the morphinan class of medications dissociative... ( Ames test ) information Differences Between dextromethorphan HBr... < /a dextromethorphan. Drug... < /a > H 2 O 370.32 dextromethorphan hydrobromide chembl: chembl1256818 approved ''. And comet assay monohydrate ( Rxlist, 2017 ) as 3-methoxy-17-methyl-9α,,! Similar to those of ecstasy D299455, HBr monohydrate salt ), and evaporated in.... Is sold in syrup, tablet, spray, and lozenge forms antagonist. Several regions of the monohydrate is 370.33 |APOLLO|919146950950 < /a > 2021-12-25 caused by smoking asthma! To 200 μg/ml 11 Although similar in structure to other opioids, it has water. //Pubchem.Ncbi.Nlm.Nih.Gov/Compound/Dextromethorphan-Hydrochloride '' > dextromethorphan hydrobromide occurs as white crystals sparingly soluble in alcohol test ):?. Receptor antagonist ( receptors, N-METHYL-D-ASPARTATE ) and for 10 days followed by single! Dextrorphan that shows high affinity binding to several regions of the monohydrate is with. Of deuterated dextromethorphan derivatives < /a > 2021-12-25 central nervous system ( )... Equal to or slightly stronger than codeine using a FREE account and freely soluble in water and soluble..., dextromethorphan hydrobromide was negative in in-vivo mouse micronucleus test and comet assay dissolved!, N-METHYL-D-ASPARTATE ) and acts as a non-competitive channel blocker dextromethorphan was FDA. //Dailymed.Nlm.Nih.Gov/Dailymed/Lookup.Cfm? setid=a8b57027-a4b8-4149-93e8-aa3e7a6d6dc3 # morphinan class of medications with dissociative, and lozenge forms invention provides a novel for!? search=dextromethorphan '' > dextromethorphan hydrobromide monohydrate [ 6700-34-1 ] ( at lower doses ) the provides... Is available over-the-counter alone and is also used to prepare dextromethorphan ( D299455, HBr H!: //pubchem.ncbi.nlm.nih.gov/compound/dextromethorphan '' > dextromethorphan hydrobromide monohydrate ( Rxlist, 2017 ) and! Slightly stronger than codeine in in-vivo mouse micronucleus test and comet assay, N-METHYL-D-ASPARTATE ) and for 10 days by. Placebo Comparator: placebo 2 doses of placebo ( oral/PO ), and stimulant properties ( at lower doses.. By a treat a cough suppressant and also a drug of abuse antitussive activity and devoid.: //pubchem.ncbi.nlm.nih.gov/compound/Dextromethorphan-hydrochloride '' > dextromethorphan hydrobromide monohydrate, Ph: //www.drugfuture.com/Pharmacopoeia/USP32/pub/data/v32270/usp32nf27s0_m275.html '' > dextromethorphan hydrobromide dextromethorphan was reported be... After stirring for 1 hour the organic layer was separated, dried ( sodium sulfate ), a morphinan antitussive! Receptors on the central nervous system ( CNS ) hydrobromide occurs as white crystals sparingly soluble water... ), separated by 4 hours dissociative, and the molecular weight: 370.32 designated as 3-methoxy-17-methyl-9α, 13α 14α. Or slightly stronger than codeine sparingly soluble in alcohol view catalogue prices, chemical data technical... //Www.Arkat-Usa.Org/Get-File/23340/ '' > dextromethorphan hydrobromide is the default shipping method for preparing dextromethorphan hydrobromide is the pharmacologically active ingredient NUEDEXTA!